论文部分内容阅读
在感染艾滋病病人中某些皮肤肿瘤发生率和病程有改变。艾滋病病人CD4淋巴细胞减少导致恶性肿瘤危险性增加,细胞免疫功能障碍减少对肿瘤的监督和生成肿瘤病毒抑制,因此增加皮肤恶性肿瘤的发生率。艾滋病病人常见皮肤恶性肿瘤有淋巴瘤、急性黑素瘤、鳞状细胞癌、基底细胞癌、Kaposi氏肉瘤等。其中恶性黑素瘤(MM)和鳞状上皮癌(SCC)是HIV感染病程中皮肤恶性肿瘤的代表,且较有侵袭性。其他如基底细胞癌(BCC)在这类人群中更为常见,但并非更具侵袭性。随着抗HIV治疗(ART)的开展,HIV伴发Kaposi肉瘤的发病率明显减低。本文论述了此类高危人群中皮肤恶性肿瘤的预防、治疗和随访策略。
In infected with AIDS in some skin cancer incidence and duration of change. AIDS patients CD4 lymphopenia lead to an increased risk of malignant tumors, cellular immune dysfunction to reduce tumor surveillance and generate tumor virus inhibition, thus increasing the incidence of skin cancer. AIDS patients with common skin malignancies are lymphoma, acute melanoma, squamous cell carcinoma, basal cell carcinoma, Kaposi’s sarcoma and so on. Among them, malignant melanoma (MM) and squamous cell carcinoma (SCC) are the representatives of skin malignancies in the course of HIV infection and are more aggressive. Others, such as basal cell carcinoma (BCC), are more common in this population, but not more aggressive. With the advent of anti-HIV treatment (ART), the incidence of HIV-associated Kaposi’s sarcoma is significantly reduced. This article discusses the prevention, treatment and follow-up strategies for skin malignancies in these high-risk groups.