论文部分内容阅读
目的 :探讨不同辛伐他汀剂量的调脂疗效、安全性和预防心脏性事件的作用.方法 :将 115例高脂血症随机单盲分为 2组 :10 m g组 5 7例 ,辛伐他汀 10 m g/ d;2 0 m g组 5 8例 ,辛伐他汀 2 0 m g/ d,均观察 1年 ,观察调脂效果、不良反应及心脏性事件发生情况.结果 :2 0 mg组治疗后总胆固醇 ( TC)、甘油三酯 ( TG)、 L DL - C、载脂蛋白 ( Apo) B均明显下降 ( P0 .0 5 ).发生 NSAP的危险性下降 ,( P“,”Objective: To investigate the efficacy and safety of two different doses of simvastatin in the treatment of dyslipidemia,and their effects on preventing cardiac events Methods: 115 cases of dyslipidemia were randomly assigned into two groups,the former(group A,57 cases)given simvastatin 10 mg nightly,while the latter(group B,58 cases)20 mg nightly Patients of both groups were observed for one year. Results: Total cholesterol(TC),triglycerin(TG),low density lipoprotein cholesterol(LDL C),apoprotein B were decreased ( P <0 01),while high density lipoprotein cholesterol(HDL C),apoprotein A 1 increased( P <0 05, P <0 01)after the therapy in both groups The amplitudes changed of these items were larger in group B than in group A( P <0 01) Percentage of patients that reached target TC and LDL C were higher in group B than in group A( P <0 01) The incidences of attack by unstable angina pectoris,nonfatal myocardiol infarction,heart failure, percutaneous transluminal angioplasty(PTCA)/coronary artery bypass grafting(CABG) in group B were lower than in group A after one year( P <0 05) Adverse reactions were mild and similar in both groups There was no patient being admitted in hospital,suffering from permanent disability,neoplasm due to taking simvastatin Conclusion: Simvastatin 20 mg/d is more suitable in treating dyslipidemia and preventing cardiac events,and is of a good tolerability profile