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[目的]观察曲昔派特治疗胃溃疡的疗效。[方法]将胃溃疡患者随机分为试验组和对照组。试验组,61例,治疗用曲昔派特(100mg/次,tid,餐后服用)加模拟雷尼替丁安慰剂(1粒/次,bid,早餐前及睡前服用);对照组,60例,治疗用雷尼替丁(150mg/次,bid,早餐前及睡前服用)加模拟曲昔派特安慰剂(1片/次,tid,餐后服用)。治疗8周后评估2组主要临床症状、内镜下溃疡愈合率、胃液分析及血清胃泌素结果。[结果]试验组、对照组主要临床症状缓解率分别为88.5%、93.3%,内镜下溃疡愈合率分别为86.9%、95%;2组比较差异均无统计学意义(P>0.05)。对照组治疗后胃酸分泌值、血清胃泌素均较治疗前有所降低(P<0.05、P<0.01),而试验组治疗前、后比较差异无统计学意义(P>0.05)。[结论]曲昔派特在不影响胃酸分泌的情况下对胃溃疡的疗效可达到与雷尼替丁相当程度。
[Objective] To observe the curative effect of trabestad in the treatment of gastric ulcer. [Methods] Patients with gastric ulcer were randomly divided into experimental group and control group. In the experimental group, 61 patients were treated with triamcinolone acetonide (100mg / time, tid, after meals) and ranitidine placebo (1 capsule / time, bid before breakfast and before going to bed) 60 patients were treated with ranitidine (150mg / time, bid, before breakfast and before going to bed) plus moxibustion placebo tablets (1 tablet / time, tid, after meals). After 8 weeks of treatment, two groups of major clinical symptoms, ulcer healing rate under endoscopy, gastric juice analysis and serum gastrin were evaluated. [Results] The remission rates of the main clinical symptoms in the experimental group and the control group were 88.5% and 93.3%, respectively. The healing rates of endoscopic ulcer were 86.9% and 95% respectively. There was no significant difference between the two groups (P> 0.05). The gastric acid secretion and serum gastrin in the control group were lower than those before treatment (P <0.05, P <0.01), but there was no significant difference in the experimental group before and after treatment (P> 0.05). [Conclusion] The effect of trazapride on gastric ulcer can reach the level of ranitidine without affecting the gastric acid secretion.