论文部分内容阅读
目的探讨急性酒精中毒急诊应用醒脑静治疗的疗效及安全性。方法将2013年3月—2014年3月本院急诊科收治的急性酒精中毒患者90例采用数字随机表法分为2组各45例,入院后均给予常规酒精中毒治疗,在此基础上对照组给予纳洛酮注射液治疗,观察组给予醒脑静注射液治疗,评估临床疗效及不良用药反应,记录2组患者的清醒时间、症状消失时间、能独立行走时间,对比治疗前后机体炎性因子变化。计量资料比较采用t检验,计数资料比较采用χ~2检验,P<0.05为差异有统计学意义。结果观察组治疗有效率为93.33%,显著高于对照组的77.78%,差异有统计学意义(P<0.05)。观察组清醒时间、症状消失时间和能独立行走时间[(1.96±1.18)、(4.19±1.85)、(6.97±2.06)h]均显著短于对照组[(3.28±1.09)、(6.02±1.86)、(9.02±2.17)h],差异均有统计学意义(均P<0.05)。观察组患者治疗后TNF-α、IL-6[(2.05±0.36)μg/L、(21.26±4.28)ng/L]显著低于对照组[(2.30±0.28)μg/L、(26.97±5.39)ng/L],ET-1[(59.64±8.63)ng/L]显著高于对照组[(47.64±9.57)ng/L],差异均有统计学意义(均P<0.05)。结论醒脑静注射液治疗急性酒精中毒可缩短术后恢复时间,安全有效。
Objective To investigate the efficacy and safety of emergency treatment of Xingnaojing in patients with acute alcoholism. Methods 90 patients with acute alcoholism admitted to our hospital emergency department from March 2013 to March 2014 were divided into two groups (n = 45) by random number table. After admission, all patients were given conventional alcoholism. On the basis of this, Group were treated with naloxone injection. The observation group was treated with xingnaojing injection to evaluate the clinical curative effect and adverse drug reaction. The awake time, the disappearance of symptoms and the independent walking time were recorded in two groups. The body inflammation was compared before and after treatment Factors change. Measurement data were compared using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The effective rate of the observation group was 93.33%, which was significantly higher than that of the control group (77.78%), the difference was statistically significant (P <0.05). The awake time, the disappearance of symptoms and the independent walking time in the observation group [(1.96 ± 1.18), (4.19 ± 1.85), (6.97 ± 2.06) h] were significantly shorter than those in the control group [(3.28 ± 1.09), (6.02 ± 1.86 ), (9.02 ± 2.17) h], the difference was statistically significant (all P <0.05). The levels of TNF-α and IL-6 in the observation group were significantly lower than those in the control group [(2.30 ± 0.28) μg / L [(2.05 ± 0.36) μg / L, [21.26 ± 4.28] ng / L] ) were significantly higher than those in the control group [(47.64 ± 9.57) ng / L], ET-1 [(59.64 ± 8.63) ng / L] Conclusion Xingnaojing injection in the treatment of acute alcoholism can shorten the recovery time, safe and effective.