Degree-degree correlation and heterogeneity in degree are important topological properties characterizing scale-free networks. We consider an evolutionary prisoners’ dilemma game on scale-free networks and investigate how degree-degree correlation influences cooperation. It is found that the cooperator frequency displays resonance-like behavior with the variation of Pearson correlation coefficient. A measure on local heterogeneity in a network is proposed and it is realized that cooperation is proportional to the local heterogeneity.