论文部分内容阅读
目的:探讨参芪扶正注射液配合化疗治疗进展期胃癌的疗效及不良反应。方法:按随机分组的方法将60例进展期胃癌患者分为治疗组和对照组,每组30例,治疗组在PCF方案化疗治疗基础上应用参芪扶正注射液,对照组只采用PCF方案治疗,具体用药剂量及方法与治疗组相同。结果:治疗组和对照组有效率分别为60.00%、56.67%,经χ2检验两者差异无统计学意义(χ2=0.067,P>0.05);在免疫学指标方面,治疗组治疗前后T细胞亚群变化无统计学意义(P>0.05),对照组治疗前后T细胞亚群变化均有统计学意义,CD3、CD4、CD4/CD8较治疗前降低(P<0.05),CD8较治疗前升高(P<0.05);在外周血象方面,治疗组治疗前后血象变化无统计学意义,对照组治疗后WBC、NE、PLT及Hb较治疗前降低(P<0.05);在毒副反应方面,治疗组和对照组引起消化道反应、肝肾方面的损害,但对照组损害程度低于治疗组(P<0.05),且两组治疗前后在体质量、生存质量的差异具有统计学意义(P<0.05)。结论:参芪扶正注射液配合化疗治疗尽管在近期疗效方面与对照组无异,但其能显著提高进展期胃癌患者的免疫功能和提高他们的生活质量,并减轻化疗带来的毒副反应,值得临床上推广应用。
Objective: To investigate the efficacy and adverse reactions of Shenqi Fuzheng injection combined with chemotherapy in the treatment of advanced gastric cancer. Methods: Sixty patients with advanced gastric cancer were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group received Shenqi Fuzheng Injection on the basis of PCF regimen and the control group received only PCF regimen , The specific dosage and method of treatment with the same treatment group. Results: The effective rates of the treatment group and the control group were 60.00% and 56.67%, respectively. There was no significant difference between the two groups (χ2 = 0.067, P> 0.05) by χ2 test. In terms of immunological parameters, The changes of T cell subsets in the control group before and after treatment were statistically significant. The levels of CD3, CD4 and CD4 / CD8 in the control group were significantly lower than those before the treatment (P <0.05) (P <0.05). There was no significant difference in peripheral blood hemoglobin before and after treatment in the treatment group, WBC, NE, PLT and Hb in the control group after treatment were lower than those before treatment (P <0.05) Group and control group caused digestive tract reactions, liver and kidney damage, but the degree of damage in the control group was lower than that in the treatment group (P <0.05), and the differences in body weight and quality of life before and after treatment were statistically significant (P < 0.05). Conclusion: Shenqi Fuzheng injection combined with chemotherapy can improve the immune function and quality of life of patients with advanced gastric cancer significantly, and reduce the toxic and side effects caused by chemotherapy, though it is no different from the control group in the short term efficacy. Worth clinical application.