天然杀伤(NK)细胞是一种对多种肿瘤细胞具有自发细胞毒效应的淋巴细胞。由于其在体内水平高,且不需长期活化,因此被认为在对自发肿瘤的早期免疫监视上发挥重要作用。目前还不清楚NK是如何识别靶细胞的,虽然有人设想NK的靶细胞上有NK特异性受体能识别的独特的抗原。最近Mcingeon等报告:预先将靶细胞用4F2单克隆抗体处理,可防止被克隆化NK细胞杀 Natural killer (NK) cells are lymphocytes that have a spontaneous cytotoxic effect on a variety of tumor cells. It is thought to play an important role in early immune surveillance of spontaneous tumors because of its high in vivo level and its lack of long-term activation. It is unclear how NK recognizes target cells, although it is contemplated that there are unique antigens recognized by NK-specific receptors on NK target cells. Recently Mcingeon et al reported that pre-treatment of target cells with a 4F2 monoclonal antibody prevented the cloned NK cells from killing