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支气管扩张剂在治疗学上分为三类支气管的舒缩反应依赖于 cAMP 和cGMP 之间的平衡。cAMP 为支气管扩张的介质,cGMP 为支气管收缩的介质。支气管扩张剂可分为三类:1.抗胆碱能药,阻断乙酰胆碱诱导 cGMP 形成;2.β-肾上腺素能受体激动剂,刺激 cAMP 形成增加;3.甲基黄嘌呤类,抑制 cAMP 为磷酸二酯酶所破坏,并可能对支气管平滑肌的紧张性有直接作用。提出了有关的生化途径之后,在理论上便可以期望各药之间会发生有益的相加或协同作用。体外虽证明它们对支气管扩张具有协同作用,但体内研究则指出,它们只具
Bronchodilator therapy is divided into three types of bronchoconstriction depends on the balance between cAMP and cGMP. cAMP bronchodilator medium, cGMP bronchoconstriction of the medium. Bronchodilators can be divided into three categories: 1. Anticholinergics that block acetylcholine-induced cGMP formation; 2. Beta-adrenergic receptor agonists that stimulate cAMP formation to increase; 3. Methylxanthines that inhibit cAMP is disrupted by phosphodiesterase and may have a direct effect on the tension of bronchial smooth muscle. After the relevant biochemical pathways have been proposed, it is theoretically possible to expect beneficial additions or synergies between the drugs. Although in vitro proved that they have synergistic effects on bronchiectasis, but in vivo studies have pointed out that they only