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目的探讨瑞芬太尼-氯胺酮在小儿静脉麻醉中的有效性和安全性,并为深入的研究提供一定依据。方法选取海军安庆医院2012年12月至2014年12月收治的52例择期手术患儿,按照入院时间的先后将其分成实验组与对照组,对照组采用氯胺酮进行静脉麻醉,实验组在对照组的基础上加入瑞芬太尼进行联合静脉麻醉,采用统计分析软件对两组患儿用药后的临床效果进行对比。结果实验组患儿的心率、无创血压以及血氧饱和度明显优于对照组,且实验组患儿氯胺酮的用量及苏醒时间明显少(短)于对照组;此外,调查两组患儿生活质量评分可知,实验组患儿生活质量评分明显优于对照组,两组比较差异有统计学意义(P<0.05)。结论在对小儿进行静脉麻醉时选择瑞芬太尼-氯胺酮用药,能够提高临床用药的效果,且有效的减少患儿氯胺酮的用量,提高用药的安全性,临床效果显著,值得推广应用。
Objective To investigate the effectiveness and safety of remifentanil-ketamine in pediatric intravenous anesthesia and to provide some evidence for further study. Methods Fifty-two children undergoing elective surgery admitted from December 2012 to December 2014 in Anqing Hospital of the Chinese People’s Armed Police Forces were divided into experimental group and control group according to the time they were hospitalized. In the control group, ketamine was used for intravenous anesthesia. In the control group Based on the introduction of remifentanil for intravenous anesthesia, the use of statistical analysis software to compare the clinical effects of two groups of children after treatment. Results The heart rate, noninvasive blood pressure and oxygen saturation of the experimental group were significantly better than those of the control group, and the dosage and recovery time of ketamine in the experimental group were significantly less (short) in the control group. In addition, the quality of life The score shows that the quality of life score of children in experimental group is obviously better than that of control group. There is significant difference between the two groups (P <0.05). Conclusion The choice of remifentanil-ketamine for intravenous anesthesia in pediatric patients can improve the effect of clinical medication, reduce the dosage of ketamine in children and improve the safety of medication. The clinical effect is worthy of popularization and application.