论文部分内容阅读
目的:制备尼莫地平亲水凝胶骨架片,并考察其体外释药特性。方法:以泊洛沙姆188和PEG6000为载体材料制备尼莫地平固体分散体,以羟丙甲纤维素(HPMC)为骨架材料制备尼莫地平缓释片。结果:缓释片的处方为尼莫地平固体分散体60mg,HPMC80mg,十八醇30mg,体外持续释药12h以上,符合Higuchi方程Qt=31.09t1/2-18.45,r=0.9961,释药机制为药物扩散和骨架溶蚀的协同作用。结论:缓释片处方合理,工艺稳定,具有长效的特点。
Objective: To prepare nimodipine hydrophilic gel matrix tablets and study its in vitro release characteristics. Methods: The solid dispersion of nimodipine was prepared with poloxamer 188 and PEG6000 as the carrier material, and the sustained release tablets of nimodipine were prepared by using hypromellose (HPMC) as the matrix material. Results: The sustained-release tablets were prepared by solid dispersion of nimodipine 60mg, HPMC 80mg, octadecanol 30mg, sustained release in vitro 12h or more, in line with Higuchi equation Qt = 31.09t1 / 2-18.45, r = 0.9961, release mechanism Synergistic effect of drug diffusion and skeleton erosion. Conclusion: Sustained-release tablets prescription is reasonable, process stability, with long-lasting characteristics.