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秋水仙碱为一种脂溶性有较长半衰期和较高生物利用率的生物碱,由于具有抗炎作用,最初被应用于治疗预防急性痛风和预防自身炎症性疾病的发作。它主要的作用机理是通过结合微管蛋白抑制微管的聚合,从而干扰白细胞及细胞因子的功能来发挥抗炎作用。随着人们对它的药理和毒理机制研究的不断深入,发现它特有的抗炎性在心包炎、冠脉疾病、房颤以及心衰等心血管疾病的防治中可发挥着重要的作用,现就将秋水仙碱在心血管系统的研究进展做一综述。
Colchicine, a fat-soluble alkaloid with long half-life and high bioavailability, has been initially used as a treatment for the prevention of acute gout and for the prevention of the onset of inflammatory diseases due to its anti-inflammatory properties. Its main mechanism of action is to exert its anti-inflammatory effect by inhibiting the polymerization of microtubules by means of tubulin, thereby interfering with the functions of leukocytes and cytokines. With the deepening of the research on its pharmacological and toxicological mechanisms, it has been found that its unique anti-inflammatory activity plays an important role in the prevention and treatment of cardiovascular diseases such as pericarditis, coronary artery disease, atrial fibrillation and heart failure, Now colchicine in the cardiovascular system to make a review of the progress.