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目的：探索藏药复方红景天（ＲＣＯ）和复方参芪花粉合剂（ＡＣＯ）对高原急性肺损伤（ＡＬＩ）早期的防治作用。方法：２４只兔和１２０只小鼠随机分为生理盐水对照组（ＮＣＧ）、盲肠结扎穿孔（ＣＬＰ）致伤组（ＩＧ），ＡＣＯ防治组（ＡＣＯＧ）、ＲＣＯ防治组（ＲＣＯＧ）。致伤前后按时测定体、肺血流动力学，血气和血、组织匀浆中的血栓素Ｂ２（ＴＸＢ２）、６酮前列腺素Ｆ１α（６ｋｅｔｏＰＧＦ１α）各指标参数。结果：各组动脉血氧分压（ＰａＯ２）和平均肺动脉压（ＭＰＡＰ）在致伤前已出现差异，ＲＣＯＧ和ＮＣＧ及ＩＧ比较，Ｐ均＜０．０５。术后４小时、８小时各组ＰａＯ２、ＴＸＢ２、６ｋｅｔｏＰＧＦ１α变化更明显，ＡＣＯＧ、ＲＣＯＧ与ＮＣＧ及ＩＧ比较，Ｐ＜０．０５或Ｐ＜０．０１。术后１２小时，ＡＣＯＧ和ＲＣＯＧ的平均体动脉压（ＭＡＰ）仍保持ＮＣＧ水平，与ＩＧ比较，Ｐ均＜０．０１。结论：藏药ＲＣＯ和ＡＣＯ在防治高原ＡＬＩ中可能起到重要防护作用
Objective: To explore the preventive and therapeutic effects of Tibetan medicine compound Rhodiola rosea (RCO) and compound Shenqi pollen mixture (ACO) on early acute lung injury (ALI) in high altitude. METHODS: Twenty-four rabbits and 120 mice were randomly divided into normal saline control group (NCG), cecal ligation and puncture (CLP) injury group (IG), ACO prevention group (ACOG), and RCO prevention group (RCOG). Before and after injury, body and lung hemodynamics were measured, and the parameters of thromboxane B2 (TXB2) and 6 keto prostaglandin F1α (6ketoPGF1α) in blood gas, blood and tissue homogenate were measured. Results: The arterial oxygen partial pressure (PaO2) and mean pulmonary arterial pressure (MPAP) in each group were different before injury. RCOG was compared with NCG and IG, P<0.05. The change of PaO2, TXB2, and 6ketoPGF1α in each group was more obvious at 4 hours and 8 hours after operation. The ACOG and RCOG were compared with NCG and IG, P<0.05 or P<0.01. At 12 hours after surgery, the mean arterial pressure (MAP) of ACOG and RCOG remained at the NCG level. Compared with IG, P was less than 0.01. Conclusion: Tibetan medicine RCO and ACO may play an important protective role in the prevention and treatment of high altitude ALI