自身免疫性溶血性贫血(AIHA)是一组由B淋巴细胞功能异常亢进、免疫功能紊乱产生抗自身红细胞的抗体,致使红细胞加速破坏而引起的贫血[1]。由于多数患者抗人球蛋白试验(包括直接和间接Coombs试验)为阳性,所以会导致血型鉴定困难和交叉配血试验有凝集,给临床用血造成很大的困扰。AIHA患者自身血液也凝集,所以患者对贫血具有一定耐受能力,如非重度贫血或抢救,输血科工作人员 Autoimmune hemolytic anemia (AIHA) is a group of anti-autologous erythrocytes, which are caused by abnormally functioning B lymphocytes and immune dysfunction, resulting in the anemia caused by accelerated destruction of red blood cells [1]. Since most patients are positive for anti-human globulin tests (including both direct and indirect Coombs tests), they can cause difficulties in blood type identification and cross-matching blood tests, posing a serious problem for clinical use of blood. AIHA patients also have their own blood coagulation, so patients with anemia has some tolerance, such as non-severe anemia or rescue, blood transfusion staff