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根据医疗产品安全应用准则,为了评价韩国产药针用蜂毒液的安全性,对家兔进行了皮肤、眼球、皮下和肌肉的刺激实验。结果:①药针用蜂毒液皮肤刺激实验显示,当蜂毒液涂在皮肤上时,未产生任何刺激反应;②眼刺激实验中观察到,蜂毒液一旦与眼粘膜相接触.即产生中、重度的刺激反应;③皮下和肌肉刺激实验显示,皮下和肌肉注射蜂毒液后可产生诸如细胞坏死、炎性细胞浸润、水肿和充血等局部炎性反应。药针用蜂毒液的研
According to the guidelines for safe application of medical products, in order to evaluate the safety of bee venom used in producing needles in Korea, rabbits were subjected to skin, eyeball, subcutaneous and muscle stimulation experiments. RESULTS: A skin irritation experiment with bee venom showed that when the bee venom was applied to the skin, no irritative reaction was produced; in the 2 eye irritation experiment, the bee venom was once in contact with the mucous membranes of the eye, ie, moderate and severe The stimulus response; 3 subcutaneous and muscle stimulation experiments show that subcutaneous and intramuscular injection of bee venom can produce such as cell necrosis, inflammatory cell infiltration, edema and hyperemia and other local inflammatory reactions. Drug Needle Bee Venom