The effect of Batroxobin expression of neural cell adhesion molecule(NCAM)in left temporal ischemicrats with spatial memory disorder was investigated by means of Morri’s water maze andimmunohistochemical methods.The results showed that the mean reaction time and distance oftemporal ischemic rats for searching a goal were significantly longer than those of sham-operated ratsand at the same time NCAM expression of left temporal ischemic region was significantly increased.However,the mean reaction time and distance of Batroxobin-treated rats were shorter and they usednormal strategies more often and earlier than those of ischemic rats.The number of NCAM immunereactive cells of Batroxobin-treated rats was more than that of ischemic group.In conclusion,Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of theexpression of NCAM is probably related to the neuroprotective mechanism. The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemicrats with spatial memory disorder was investigated by means of Morri’s water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they usednormal strategies more often and earlier than those of ischemic rats. The number of NCAM immunereactive cells of Batroxobin-treated rats was more than that of ischemic group.In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of theexpression of NCAM is probably relatedto the neuroprotective mechanism.