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目的:探讨高海拔地区妇女实施体外受精-胚胎移植(IVF-ET)卵胞浆内单精子注射(ICSI)术后的妊娠结局。方法:对自2003年5月—2008年5月在我中心实施IVF-ET及ICSI共216周期中获临床妊娠的81例患者,84个妊娠周期的结局及围产儿情况进行回顾性分析。结果:216个IVF-ET及ICSI周期临床妊娠率38.9%(84/216),自然流产率25%(21/84),异位妊娠(EP)率3.57%(3/84),多胎妊娠率28.57%(24/84),单胎剖宫产率27.78%(10/36),双胎剖宫产率76.47%(13/17),早产率16.98%(9/53),先天性出生缺陷率1.43%(1/70),均与国内报道相一致;低体重儿出生率40%(28/70),其中单胎低体重儿出生率22.22%(8/36),双胎低体重儿出生率58.82%(20/34),较国内报道显著增高。结论:我中心位于高海拔地区IVF-ET技术亦达到与国内同等水平的临床妊娠率及较好的妊娠结局,但高海拔缺氧环境使低体重儿出生率显著增高。
OBJECTIVE: To investigate the pregnancy outcomes of intravitreal injections of intracytoplasmic sperm (IVF-ET) after high-altitude women undergo IVF-ET. Methods: From May 2003 to May 2008, 81 patients with clinical pregnancy in 216 cycles of IVF-ET and ICSI were enrolled in our center. The outcome of 84 gestational cycles and the status of perinatal children were analyzed retrospectively. Results: The clinical pregnancy rates in 216 cycles of IVF-ET and ICSI were 38.9% (84/216), spontaneous abortion rates of 25% (21/84), ectopic pregnancies (EP) rates of 3.57% (3/84) 28.57% (24/84), 27.78% (10/36) with single cesarean section, 76.47% (13/17) with twin cesarean section, 16.98% (9/53) with premature birth, congenital birth defects Rate of 1.43% (1/70), all of which were consistent with those reported in China. The birth rate of low birth weight children was 40% (28/70), of which 22.22% (8/36) were singleton low birth weight children and 58.82 % (20/34), which is significantly higher than that in China. Conclusion: The IVF-ET technique with high center of gravity in our country has reached the same level of clinical pregnancy rate and better pregnancy outcome in China. However, the incidence of low birth weight children is significantly higher in high altitude and anoxia environment.