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目的 观察目前上海地区急性冠脉综合征 (ACS)患者早期他汀类药物的使用情况及其对病死率的影响。方法 采用多中心回顾性队列研究的方法 ,依据是否使用他汀类药物将上海市 16所二、三级医院的114 3例ACS患者分为他汀组和非他汀组 ,观察两组病死率的差别。结果 ACS患者中应用他汀类药物者占6 5 .2 % (74 5 / 114 3例 ) ,发病 2 4h内应用他汀类药物者占 6 2 .8% (4 6 8/ 74 5例 ) ,提示本组早期使用他汀类药物的患者比例较高 ;他汀组的病死率 (3.4 8% )显著低于非他汀组 (8.2 9% ,P =0 .0 0 1)。结论 目前 ,上海地区大多数患者能得到早期他汀类药物治疗 ,而早期使用他汀类药物可降低ACS患者的病死率。
Objective To observe the early statin use in patients with acute coronary syndrome (ACS) in Shanghai and its effect on mortality. Methods According to the retrospective cohort study, 1143 ACS patients in 16 secondary and tertiary hospitals in Shanghai were divided into two groups: statin group and non-statin group. The difference of mortality was observed between two groups. Results Among the ACS patients, 65.2% (74 5/114) were statins and 62.8% (468/74 5) patients were statins within 24 hours after onset, suggesting that The proportion of patients who used statins early was higher in this group. The mortality rate in statin group (3.4% vs 8%) was significantly lower than that in non-statin group (8.2%, P = 0.010). Conclusions At present, most patients in Shanghai can get early statin treatment. However, the early use of statins can reduce the mortality of ACS patients.