亚急性硬化性全脑炎(SSPE)是指麻疹后脑炎的亚急性和慢性形式而言。本病特征为初起时精神萎靡,晚期呈进行性神经机能失调(如惊厥、昏迷),患者通常在1～2年内死亡。该病潜伏期很长,从感染麻疹到神经体征初现,其间约距6年。组织学损害遍及中枢神经系统。脑实质小静脉周围见淋巴细胞和浆细胞呈套状浸润。类似改变还可见于软脑膜。此外可见小胶质细胞和星形胶质细胞不同程度增生。髓鞘脱失主要见于患病时间持续较长的病例。可发现不同数目的胞核 Subacute sclerosing full encephalitis (SSPE) refers to the subacute and chronic forms of post-measles encephalitis. The disease characterized by apathetic apathetic, advanced progressive neurological disorders (such as convulsions, coma), the patient usually within 1 to 2 years of death. The incubation period of the disease is very long, from the initial infection of measles to neurological signs, during which about 6 years. Histological damage throughout the central nervous system. Around the parenchymal small veins see lymphocytes and plasma cells were infiltrated. Similar changes can also be found in the pia mater. In addition, it can be seen that microglia and astrocytes proliferate to varying degrees. Demyelination is mainly seen in cases of longer duration of illness. Different numbers of nuclei can be found