本文利用倍增差示法消除脑清片中氨基比林、咖啡因的相互干扰,配平倍数m=2.188,n=2.086,用UV-260分光光度计在254nm和274nm处,分别测定氨基比林和咖啡因的含量。回收率分别为99.4％和100.0％,变异系数分别为0.37％和0.77％.测定两批脑清片,氨基比林和咖啡因的含量分别为97.6％和99.6％;91.3％和91.5％,与中国药典法比较,结果一致。 In this paper, the multiplicative differential method was used to eliminate the interference of aminopyrine and caffeine in brain slices. The multiple of m = 2.188 and n = 2.086. The UV-260 spectrophotometer was used to determine the ratio of aminopyrine and caffeine in 254nm and 274nm respectively. Caffeine content. The recoveries were 99.4% and 100.0%, respectively, and the coefficients of variation were 0.37% and 0.77%, respectively.The contents of two groups of tablets, aminopyrine and caffeine were 97.6% and 99.6%, 91.3% and 91.5% Chinese Pharmacopoeia comparison, the results are consistent.