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甲基多巴可使20%的病人 Coomb 试验阳性,并已证实甲基多巴与扰核抗体的出现有明确关系。本文报告1例服用甲基多巴期间发生狼疮样综合征。病人女性,48岁。因不适、全身乏力、关节痛、晨起肢体僵硬和霭诺氏现象12个月入院。病人因高血压服用甲基多巴250mg,每日3次已2年。体检除血压180/100mmHg 外,无异常发现。眼底检查、心电图和胸部 X 线照片均正常。血糖、血肌酐、尿酸盐、电解质浓度、肝功能及蛋白电泳测定均正常。同位素分侧肾功能测定及静脉快速连续摄片肾盂造影亦正常。血沉第1小时24mm。直接 Coomb 试验和狼疮细胞检查阳性,类风湿因子阴性,抗核抗体阳性,抗甲状腺微粒体抗体滴定度1∶6,400。扰平滑肌抗体、
Methyl dopa can make 20% of patients Coomb test positive, and confirmed that there is a clear relationship between methyldopa and the emergence of interfering antibodies. This article reports 1 patient who developed lupus-like syndrome during methadopa. Patient Female, 48 years old. Due to malaise, malaise, joint pain, early morning stiffness and azoospermia Knox phenomenon was admitted to hospital for 12 months. Patients taking methyldopa 250mg for hypertension, 3 times a day for 2 years. Physical examination except blood pressure 180 / 100mmHg, no abnormal findings. Fundus examination, electrocardiogram and chest X-ray were normal. Blood glucose, serum creatinine, urate, electrolyte concentration, liver function and protein electrophoresis were normal. Isotope side of renal function tests and rapid intravenous continuous pelvic pyelography also normal. ESR first hour 24mm. Direct Coomb test and lupus cell test positive, rheumatoid factor negative, anti-nuclear antibody-positive, anti-thyroid microsomal antibody titer 1: 6,400. Disturbing smooth muscle antibodies,