1-正癸基吡唑烷-3-酮(Ⅱ结构式见表1)是欧洲专利报道的一种新型减肥剂。White等报道该化合物可通过血脑屏障,并对γ-氨基丁酸氨基转移酶(GABA-T)有强烈的抑制活性,但对谷氨酸脱羧酶的抑制作用较弱,因此可引起脑内γ-氨基丁酸(GABA)水平的升高,故我们相信应有抗惊活性。经我们合成后,发现Ⅱ确有良好的抗癲痫活性,抗小鼠最大电 1-n-decylpyrazolidin-3-one (structural formula in Table II) is a new type of diet-reducing agent reported in European patent. White et al. Reported that the compound can cross the blood-brain barrier and strongly inhibit γ-aminobutyric acid aminotransferase (GABA-T), but its inhibitory effect on glutamate decarboxylase is weak, γ-aminobutyric acid (GABA) levels, so we believe that there should be anti-shock activity. After our synthesis, found that Ⅱ does have good anti-epileptic activity, the maximum anti-mouse power