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目的:在疫情期间,需要通过保证内镜处理质量,避免过程环节操作中的接触污染,防止气溶胶的散发,从而保护从业人员,杜绝院内感染.创新点:内镜诊疗对改善重症患者预后及降低患者死亡率有重要作用.该研究依据实际临床工作特质,对内镜再处理过程中的部分方法及化学清洗消毒剂的选择进行了改良与替换.方法:从12例重症患者行23次内镜诊治后的内镜处理操作中提取经验,结合相关指南规范,提出了新型冠状病毒肺炎患者床边内镜诊疗后内镜再处理改良流程.结论:内镜诊疗在重症及危重症患者治疗中不可或缺.临床工作中床旁预处理操作及专线转运流程对于预防院内感染具有重要意义.替换后的化学清洗消毒剂(0.23％过氧乙酸)对新冠病毒可达到高水平消毒.改良后的床边内镜诊疗后内镜再处理操作流程顺畅,感染控制严谨,值得临床进一步推广.“,”Severe cases infected with the coronavirus disease 2019 (COVID-19), named by the World Health Or-ganization (WHO) on Feb. 11, 2020, tend to present a hypercatabolic state because of severe systemic consumption, and are susceptible to stress ulcers and even life-threatening gastrointestinal bleeding. Endoscopic diagnosis and treatment constitute an irreplaceable part in the handling of severe COVID-19 cases. Endoscopes, as reusable pre-cision instruments with complicated structures, require more techniques than other medical devices in cleaning, dis-infection, sterilization, and other reprocessing procedures. From 2016 to 2019, health care-acquired infection caused by improper endoscope reprocessing has always been among the top 5 on the list of top 10 health technology hazards issued by the Emergency Care Research Institute. Considering the highly infective nature of COVID-19 and the po-tential aerosol contamination therefrom, it is of pivotal significance to ensure that endoscopes are strictly reprocessed between uses. In accordance with the national standard “Regulation for Cleaning and Disinfection Technique of Flexible Endoscope (WS507-2016),” we improved the workflow of endoscope reprocessing including the selection of chemicals in an effort to ensure quality control throughout the clinical management towards COVID-19 patients. Based on the experience we attained from the 12 severe COVID-19 cases in our hospital who underwent endoscopy 23 times in total, the article provides an improved version of endoscopic reprocessing guidelines for bedside endoscopic di-agnosis and treatment on COVID-19 patients for reference.