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直肠给药后,药物的吸收受药物理化性质,直肠的生理或解剖部位所支配。因此,为了增进药物的吸收,其制剂常常添加附加剂。这些附加剂所引起的吸收变化,可以认为是由附加剂、药物和直肠吸收面积三者之间的相互作用所产生的。但在一般情况下,往往难以简单地区别,多数情况只是阐明药物的吸收量的变化。本文主要从吸收部位的组织渗透性观点来比较附加剂对药物吸收的影响。
After rectal administration, the absorption of the drug is governed by the physicochemical properties of the drug, the physiology or anatomy of the rectum. Therefore, in order to enhance the absorption of the drug, the formulation is often added with an additive. Absorption changes caused by these additives, can be considered by the additive, drug and rectal absorption area of the interaction between the three generated. However, under normal circumstances, it is often difficult to make a simple distinction. In most cases, only the changes in the absorption of drugs are elucidated. This article mainly from the point of view of tissue permeability of the absorption site to compare the impact of additives on drug absorption.