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本文报告了新生儿窒息呼吸衰竭35例血浆血管紧张素Ⅱ（AⅡ）、内皮素（ET）及醛固酮（ALD）的动态变化，20例正常新生儿作为对照组。结果显示：AⅡ急性期值明显高于缓解期（546．80±334．52：286．44±278．0ng／L）也高于正常新生儿对照组（384．99±311．13ng／L），P＜0．01。随着缺氧程度加重AⅡ活性增高，ET急性期值也高于缓解期和正常对照组，而且急性期ALD明显高于其它组。因此，我们建议在窒息和呼吸衰竭时早期检测AⅡ、ET及ALD为使用血管扩张药以增加脑血流改善缺氧缺血脑损害提供依据。
This article reports the dynamic changes of plasma angiotensin Ⅱ (AⅡ), endothelin (ET) and aldosterone (ALD) in neonates with asphyxia and 20 normal neonates as control group. The results showed that the acute phase of AⅡwas significantly higher than that of the remission stage (546.80 ± 334.52: 286.44 ± 278.0ng / L) and higher than that of the normal neonatal control group (384.99 ± 311.13ng / L) , P <0.01. With the increase of hypoxia, the activity of AⅡ was increased, the acute phase of ET was also higher than that of remission and normal control group, and ALD in acute phase was obviously higher than other groups. Therefore, we suggest that early detection of AII, ET, and ALD during asphyxia and respiratory failure provide evidence for the use of vasodilators to increase cerebral blood flow and improve brain damage following hypoxia-ischemia.