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作者报告了西安市８６名易感的小学生接种痘苗病毒重组乙肝疫苗一年的效果观察结果。受试者随机分成３组，免疫剂量分别为２．０，５．０，１０．０μｇ，按０，１，６程序接种。结果表明，免疫后６个月各组的抗－ＨＢｓ应答率均达９６％以上；低应答率为１．２％（１／８１）．３个组免疫后６个月与１２个月的抗－ＨＢｓ几何平均滴度分别为２３９．１，２９４．７，２４１．０ｍＩＵ／ｍｌ与２３５．１，３４９．３，３３５．６ｍＩＵ／ｍｌ，３组之间均无明显差异（Ｐ＞０．０５）．与文献比较提示，本实验疫苗的免疫原性良好，５．０μｇ与１０．０μｇ组的抗－ＨＢｓ在免疫后３年将能保持较高水平。因此，痘苗重组乙肝疫苗以５．０或１０．０μｇ剂量免疫为宜。
The authors report the effect of one year of 86 vaccinated primary school students vaccinated with vaccinia virus on hepatitis B vaccine. Subjects were randomly divided into three groups, immunized doses were 2.0,5.0,10.0 g, according to 0,1,6 program inoculation. The results showed that the anti-HBs response rates of all the groups reached more than 96% at 6 months after immunization, and the low response rate was 1.2% (1/81). The geometric mean titers of anti-HBs at 6 months and 12 months after immunization in the three groups were 239.1, 294.7, 241.0 mIU / ml and 235.1, 349.3, 335.6 mIU / ml, respectively, There was no significant difference between the three groups (P> 0.05). Compared with the literature, the immunogenicity of the experimental vaccine is good, and the anti-HBs in the 5.0 μg and 10.0 μg groups will maintain a high level after 3 years of immunization. Therefore, vaccinia recombinant hepatitis B vaccine to 5.0 or 10.0 g dose of immunization is appropriate.