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本实验通过外源性 cAMP 和茶碱对人胃腺癌细胞系 SGC-7901的连续作用,观察到外源性 cAMP 和茶碱对该细胞株的增殖,具有明显的抑制作用。在透射电镜和扫描电镜下,均可见到细胞表面较光滑,微绒毛减少或消失。同时见到细胞膜表面上的 Na~+—K~+—ATP 酶活性受到抑制。本文讨论了外源性 cAMP 对人胃腺癌 SGC-7901细胞系增殖的抑制作用,以及膜表面微绒毛和Na~+—K~+—ATP 酶活性变化的关系。
In this study, exogenous cAMP and theophylline on human gastric adenocarcinoma cell line SGC-7901 continuous effect, exogenous cAMP and theophylline were observed on the proliferation of the cell line, with significant inhibitory effect. In the transmission electron microscope and scanning electron microscopy, we can see the cell surface is smooth, microvilli reduce or disappear. At the same time see the cell membrane surface Na ~ + -K ~ + -ATP enzyme activity was inhibited. This article discusses the inhibition of exogenous cAMP on the proliferation of human gastric adenocarcinoma cell line SGC-7901 and the relationship between the changes of microvilli and Na ~ + -K ~ + -ATPase activity.