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目的了解四川大学华西医院近年来检测出的丙型肝炎病毒基因型分布特点。方法收集2009年1月至2013年12月间在四川大学华西医院就诊的丙型肝炎病毒感染者的基因分型结果,分析基因型分布特征。结果 1 998例丙型肝炎病毒感染者中,共检出5种基因型、15种基因亚型,其中4例为2种基因亚型的混合感染。其基因型或亚型分布:1a型8例(0.40%)、1b型1 368例(68.47%)、1c型18例(0.90%)、2a型78例(3.90%)、2b型1例(0.05%)、2i型16例(0.80%)、3a型291例(14.56%)、3b型154例(7.71%)、3k型4例(0.20%)、5a型1例(0.05%)、6a型50例(2.50%)、6b型3例(0.15%)、6h型1例(0.05%)、6n型1例(0.05%),混合感染中1b/1c型、1b/6h型、2c/2a型、3b/3k型各1例(各占0.05%)。不同性别间主要基因亚型分布差异无统计学意义(P>0.05),不同年龄段间分布差异有统计学意义(P<0.05)。结论四川大学华西医院就诊患者丙型肝炎病毒基因亚型主要为1b亚型,其次为3a、3b、2a、6a亚型,同时还存在1a、1c、2b、2i、3k、5a、6b、6h、6n、1b/1c、1b/6h、2c/2a、3b/3k等单一或混合基因型,提示患者基因型存在多样性。
Objective To understand the distribution of hepatitis C virus genotypes detected by West China Hospital of Sichuan University in recent years. Methods The genotyping results of hepatitis C virus infected patients at West China Hospital of Sichuan University from January 2009 to December 2013 were collected to analyze the genotypic distribution. Results Among the 1 988 hepatitis C virus-infected patients, 5 genotypes and 15 genotypes were found, of which 4 were mixed infections of two genotypes. The genotypes or subtypes were as follows: type 1a 8 cases (0.40%), type 1b 1b 368 (68.47%), type 1c 18 cases (0.90%), type 2a 78 cases 0.05%), 16 cases (0.80%) of type 2i, 291 cases (14.56%) of type 3a, 154 cases (7.71%) of type 3b, 4 cases (0.20%) of type 3k, (2 cases), type 1 (6 cases), type 1 (6 cases), type 1 of 6n (0.05%), type 1b / 1c of mixed infection, type of 1b / 6h, type 2c / One type 2a and one type 3b / 3k each (0.05% each). There was no significant difference in the distribution of major genotypes between different genders (P> 0.05), and there was significant difference among different age groups (P <0.05). Conclusions The HCV genotype of patients in West China Hospital of Sichuan University is predominantly subtype 1b, followed by subtype 3a, 3b, 2a and 6a, with 1a, 1c, 2b, 2i, 3k, 5a, 6b and 6h , 6n, 1b / 1c, 1b / 6h, 2c / 2a, 3b / 3k and other single or mixed genotypes, suggesting that patients with genotype diversity.