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目的分析青少年骨肉瘤患者3年生存率影响因素。方法选择初治青少年骨肉瘤患者为研究对象并随访,分析3年生存率和临床病理因素的关系,采用Logistic回归分析其危险因素。结果本组青少年骨肉瘤患者3年生存率为60.0%,在性别、年龄、肿瘤部位、病理性骨折和病理类型方面差异无统计学意义(P均>0.05),在KPS评分、肿瘤大小和Enneking分期中的差异均有统计学意义(P均<0.05),KPS<70分、肿瘤大小≥10cm和Enneking分期晚患者3年生存率显著低于KPS≥70分、肿瘤大小<10cm和Enneking分期早患者。Logistic回归分析表明KPS评分<70分、肿瘤≥10cm和Enneking分期晚均为青少年骨肉瘤3年生存率的危险因素(P均<0.05)。结论青少年骨肉瘤患者3年生存率的影响因素包括KPS评分、肿瘤大小和Enneking分期,针对这些危险因素应积极进行预防。
Objective To analyze the influential factors of 3-year survival rate in adolescent osteosarcoma patients. Methods The patients with newly diagnosed adolescent osteosarcoma were selected and followed up. The relationship between 3-year survival rate and clinicopathological factors was analyzed. Logistic regression analysis was used to analyze the risk factors. Results The 3-year survival rate was 60.0% in patients with adolescent osteosarcoma. There was no significant difference in gender, age, tumor location, pathological fracture and pathological type (all P> 0.05). The KPS score, tumor size and Enneking The difference was statistically significant (P <0.05). KPS <70, tumor size ≥10cm and Enneking staging 3-year survival rate was significantly lower than KPS ≥70, tumor size <10cm and Enneking staging patient. Logistic regression analysis showed that KPS score <70, tumor> 10cm and Enneking staging were all risk factors for 3-year survival rate of adolescent osteosarcoma (all P <0.05). Conclusion The influencing factors of 3-year survival rate in adolescent osteosarcoma include KPS score, tumor size and Enneking staging. For these risk factors, they should be actively prevented.