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目的:探讨阿尼西坦对血管性痴呆(VD)的治疗机制。方法:用四血管阻塞改良法建立VD大鼠模型,造模后阿尼西坦灌胃4周;水迷宫检测VD大鼠学习记忆能力,免疫组织化学SABC法检测海马齿状回bcl-2的表达。结果:阿尼西坦灌胃后,VD大鼠学习记忆能力明显提高(P<0.05),海马齿状回bcl-2阳性表达比模型组明显增多(P<0.05)。结论:阿尼西坦显著改善VD大鼠的学习记忆能力,其机制可能与上调海马齿状回bcl-2表达有关。
Objective: To investigate the therapeutic mechanism of aniracetam on vascular dementia (VD). Methods: VD rat model was established by four-vessel occlusion modification method and aniracetam was given intragastrically for 4 weeks after modeling. The learning and memory abilities of VD rats were detected by water maze and the expression of bcl-2 in hippocampal dentate gyrus was detected by immunohistochemical SABC method expression. Results: After aniracetam administration, learning and memory abilities of VD rats were significantly increased (P <0.05). The positive expression of bcl-2 in dentate gyms of hippocampus was significantly increased (P <0.05). Conclusion: Aniracetam can significantly improve the learning and memory abilities of VD rats, which may be related to the up-regulation of bcl-2 expression in dentate gyrus of hippocampus.