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选择性钙通道阻滞剂氟桂嗪(flunarizine)对于脑血管床具有突出的作用;又有组胺H_1受体拮抗作用,降低血液粘滞性和血小板活性。这提示它是一个有效的抗偏头痛药。作者研究了氟桂嗪对偏头痛发作的预防效果,并与美舍吉特(methysergide)相比较。研究对象为104例门诊病人,随机列入美舍吉特(每日2mg)或氟桂嗪(每日10mg)治疗组,各为51和53例;两组间年龄、性别和病情等无明显差别。共观察6个月。治疗前1个月,治疗期5个月。
Selective calcium channel blocker flunarizine (flunarizine) on the cerebrovascular bed has a prominent role; another histamine H_1 receptor antagonism, reduce blood viscosity and platelet activity. This suggests that it is an effective anti-migraine medicine. The authors studied the prophylactic effect of flunarizine on migraine attacks and compared it with methysergide. A total of 104 outpatients were randomly assigned to receive either methachlide (2 mg daily) or flunarizine (10 mg daily) in 51 and 53 infants, respectively. There was no significant difference in age, gender, or disease between the two groups difference. A total of 6 months observation. One month before treatment, the treatment period is 5 months.