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肿瘤干细胞可能来源于正常干细胞或分化的细胞。肿瘤干细胞同正常干细胞一样具有无限的自我更新能力,能够分化成不同表型的肿瘤细胞,使肿瘤在体内不断扩大或形成新的肿瘤。肿瘤干细胞具有高度的致瘤性和耐药性,因而可能是导致肿瘤化疗失败的主要原因。肿瘤干细胞的研究不仅有助于认识和理解肿瘤发生和发展的机制,而且对肿瘤的临床治疗具有重要的指导作用。靶向肿瘤干细胞的治疗策略将可能是癌症治疗的一个新的方向。
Tumor stem cells may originate from normal stem cells or differentiated cells. Tumor stem cells, like normal stem cells, have an infinite ability of self-renewal and can differentiate into tumor cells of different phenotypes, so that the tumor continuously expands or forms new tumors in the body. Tumor stem cells are highly tumorigenic and drug-resistant, which may be the main reason for tumor chemotherapy failure. The study of tumor stem cells not only helps to understand and understand the mechanism of tumorigenesis and development, but also plays an important guiding role in the clinical treatment of tumors. Therapeutic strategies targeting cancer stem cells may be a new direction for the treatment of cancer.