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目的观察高效抗逆转录病毒治疗对艾滋病病人机体免疫重建的作用。方法以前瞻性队列研究方式对48例入组治疗病人分别在治疗前和治疗半年、1年后检测病人的外周血CD4+T细胞和血浆RNA。结果经半年和1年治疗后,外周血CD4+T细胞≥200/mm3的病例分别为30.23%和32.56%;血浆RNA≤5×102copies/ml的病例分别为62.50%和94.29%;外周血CD4+T细胞计数增量与血浆RNA病毒载量的下降幅度呈正相关关系(r=0.647,P<0.001),78例艾滋病病人治疗满1年并存活的比例为91.03%。结论通过高效抗逆转录病毒治疗,艾滋病病人的免疫功能得到了重建。
Objective To observe the effect of high effective antiretroviral therapy on immune reconstruction of AIDS patients. Methods A prospective cohort study was conducted in 48 patients treated with pretreatment and treatment of six months, one year after the test of patients with peripheral blood CD4 T cells and plasma RNA. Results After six months and one year of treatment, the cases of peripheral blood CD4 + T cells ≥200 / mm3 were respectively 30.23% and 32.56%; the cases of plasma RNA≤5x102copies / ml were 62.50% and 94.29% respectively; + T cell count was positively correlated with the decline of plasma RNA viral load (r = 0.647, P <0.001). The proportion of 78 AIDS patients who survived for one year and survived was 91.03%. Conclusion The immune function of AIDS patients has been rebuilt by highly effective antiretroviral therapy.