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目的观察中药人工周期联合二甲双胍治疗性多囊卵巢综合征(PCOS)的临床疗效。方法 52例临床患者,使用人工周期联合二甲双胍3个周期,观察治疗前后性激素水平、瘦素(Leptin)、性激素结合球蛋白(SHBG)、体重指数(BMI)和卵巢形态学等检测指标及临床表现。结果用药后LH/FSH比值、雄激素水平、瘦素较治疗前均降低,性激素结合球蛋白较治疗前显著升高,比较差异有统计学意义(P<0.01)。治疗后BMI下降,卵巢体积缩小,较治疗前比较差异有统计学意义(P<0.05)。结论中药人工周期联合二甲双胍可有效调整多囊卵巢综合征内分泌紊乱的内环境,治疗多囊卵巢综合征效佳。
Objective To observe the clinical efficacy of traditional Chinese medicine combined with metformin in treating polycystic ovary syndrome (PCOS). Methods Fifty - two patients were enrolled in the study. The levels of sex hormones, Leptin, SHBG, BMI and ovarian morphology were observed before and after treatment with three cycles of artificial cycle combined with metformin. . Results LH / FSH ratio, androgen levels, leptin were lower than those before treatment, sex hormone binding globulin was significantly higher than before treatment, the difference was statistically significant (P <0.01). After treatment BMI decreased ovarian volume decreased, compared with before treatment was statistically significant difference (P <0.05). Conclusion Chinese medicine artificial cycle combined with metformin can effectively adjust the endocrine disorders of the environment of polycystic ovary syndrome, the treatment of polycystic ovary syndrome is effective.