目的　探讨高原环境下多发性硬化 (MS)血清某些微量元素含量的变化与发病的相关性。方法　以电感耦合等离子体发射光谱法测定 19例 MS患者血清 Zn、Cu、Fe、Mn、Al等 5种微量元素水平。结果　 MS患者血清 Mn、Al水平显著高于正常对照组 ,而 Cu含量则较低。 Zn和 Fe无明显变化。结论　微量元素的改变可能与 MS的发病机制有一定联系。 Objective To investigate the correlation between the changes of some trace elements in multiple sclerosis (MS) serum and its pathogenesis in the plateau environment. Methods The levels of 5 trace elements such as Zn, Cu, Fe, Mn and Al in 19 MS patients were determined by inductively coupled plasma atomic emission spectrometry. Results The levels of serum Mn and Al in MS patients were significantly higher than those in normal controls, while the contents of Cu were lower. Zn and Fe did not change significantly. Conclusion The changes of trace elements may be related to the pathogenesis of MS.