目的：探讨粒细胞集落刺激因子（ＧＣＳＦ）与儿童哮喘发作的关系。方法：采用双抗体夹心酶标法，对３２０例哮喘发作期患儿，于发病３天内和１４天后各取血１次测定ＧＣＳＦ；并对３２０例中的１６６例于发病３天内、５天、７天、１４天分别采４次血测定ＧＣＳＦ。结果：３２０例ＧＣＳＦ阳性率为１６８８％和０６％；其中的１６６例ＧＣＳＦ阳性率分别为２７７％、２５９％、９６％和２４％。同时检测健康儿童９０例，ＧＣＳＦ全为阴性。结论：ＧＣＳＦ与儿童哮喘发作密切相关。 Objective: To investigate the relationship between granulocyte-colony stimulating factor (GCSF) and childhood asthma attack. Methods: Using double antibody sandwich enzyme-linked immunosorbent assay, 320 cases of asthma attack in children, within 3 days and 14 days after the onset of bleeding each measured G-CSF; and 166 cases of 320 cases in the onset of 3 days, 5 Day, 7 days, 14 days were taken 4 times blood G-CSF. Results: The positive rates of G-CSF in 320 cases were 1688% and 06%. The positive rates of G-CSF in 166 cases were 277%, 259%, 96% and 24% . At the same time 90 cases of healthy children, G-CSF all negative. Conclusion: G-CSF is closely related to the onset of childhood asthma.