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目的:探讨与肺癌脑转移预后相关的影响因素,为更好的治疗肺癌脑转移提供参考依据。方法:回顾性分析2002年~2009年唐都医院收治的78例肺癌脑转移的临床资料。结果:患者年龄、性别、病理类型、脑转移灶数目、颅外有无转移性病灶、患者的行为状态(PS评分)对患者生存期无显著影响(P>0.05)。但放疗+化疗治疗组疗效显著优于单纯放疗组及单纯化疗组(P<0.05),症状消失者(CR)或明显缓解者(PR)生存较无明显改善者(SD)或加重者(PD)生存期显著延长。结论:对肺癌脑转移患者应采取放疗联合化疗综合方案治疗,同时,应及时关注其症状缓解情况并指导治疗。
Objective: To investigate the influencing factors of prognosis of lung cancer with brain metastases, and to provide a reference for better treatment of brain metastases of lung cancer. Methods: The clinical data of 78 cases of brain metastases from lung cancer admitted in Tangdu Hospital from 2002 to 2009 were analyzed retrospectively. Results: The patient’s age, sex, pathological type, number of brain metastases, extracranial metastatic lesions, and patient’s behavior status (PS score) had no significant effect on the survival of patients (P> 0.05). However, the efficacy of radiotherapy + chemotherapy group was significantly better than that of radiotherapy alone group and chemotherapy alone group (P <0.05), and the survival of patients with symptoms disappeared (CR) or significant reliever (PR) ) Survival was significantly prolonged. Conclusion: Patients with brain metastasis of lung cancer should be treated with radiotherapy combined with chemotherapy, and at the same time, their symptoms should be promptly treated and guidance should be given.