抗生素组织透过性是说明药物进入靶器官后的药理和毒理效应,以及对抗菌作用的影响。抗生素组织分布和药代动力学特性对临床抗菌治疗有指导意义。作者对喹诺酮类,β-内酰胺类和氨基糖苷类药物的组织分布的异同及其抗菌作用的关系加以探讨。抗生素分布容积的早期研究,是以血清中药物浓度的变化为基础,以其与时间的关系用数学公式计算的。所以这些药物的分布容积很相象。而氨基糖苷类和β-内酰胺类抗生素在组织中的分布是很不均衡的。由于他们主要分布在细胞外液,而细胞外液仅占体 Antibiotic tissue permeability is to explain the pharmacological and toxicological effects of the drug as it enters the target organ and its effect on the antibacterial activity. Antibiotics tissue distribution and pharmacokinetic properties of antimicrobial therapy for clinical guidance. The authors discussed the similarities and differences of the tissue distribution of quinolones, β-lactams and aminoglycosides and the relationship between their antibacterial activities. An early study of antibiotic volume distribution was based on changes in serum drug concentrations and was calculated using mathematical formulas in relation to time. Therefore, the distribution of these drugs is very similar volume. The aminoglycosides and β-lactam antibiotics in the distribution of the organization is very uneven. Because they are mainly distributed in the extracellular fluid, extracellular fluid only accounts for the body