【摘 要】
：
N-methyl-tetrahydroquinolines(MTHQs) are a kind of very useful chemicals, which can be obtained from N-methylation of amines.However, the methylation of quinoli
【机 构】
：
Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and
【出 处】
：
Science China(Chemistry)
论文部分内容阅读
N-methyl-tetrahydroquinolines(MTHQs) are a kind of very useful chemicals, which can be obtained from N-methylation of amines.However, the methylation of quinolines which is a kind of highly unsaturated nitrogen-containing heterocyclic aromatic compounds has not been reported. In this work, we report the first work for the synthesis of MTHQs by methylation of quinolines using CO_2 and H_2. It was found that Ru(acac)_3-triphos [triphos: 1,1,1-tris(diphenylphosphinomethyl)ethanl] complex was very active and selective for the N-methylation reaction of quinolines, and the yield of the desired product could reach 99%.
N-methyl-tetrahydroquinolines (MTHQs) are a very kind of very useful chemicals, which can be obtained from N-methylation of amines. Note that the methylation of quinolines which is a kind of highly unsaturated nitrogen-containing heterocyclic aromatic compounds has not been reported . This work, we report the first work for the synthesis of MTHQs by methylation of quinolines using CO_2 and H_2. It was found that Ru (acac) _3-triphos [triphos: 1,1,1-tris (diphenylphosphinomethyl) ethanl] complex was very active and selective for the N-methylation reaction of quinolines, and the yield of the desired product could reach could reach 99%.
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