专利披露了以NAD和醋酸钠为原料,醋酸为溶剂,一步简单地非酶合成O-乙酰-ADP-核糖(OAADPR)。这一反应延伸到其它羧酸,例如NAD和NAD类似物之间的反应产生相应的2,-和3,羧酸酯混合物。本发明还包括其它O-羧酸-ADP-核糖化合物及其相应的合成方法(例如,O-丙酰基-ADP-核糖和O-丙二酰基-ADP-核糖),以及非腺苷核苷化合物。 Patent discloses NAD and sodium acetate as raw materials, acetic acid as a solvent, a simple non-enzymatic synthesis of O-acetyl-ADP-ribose (OAADPR). This reaction extends to the reaction of other carboxylic acids, such as NAD and NAD analogs, to produce the corresponding 2, - and 3, carboxylate mixtures. The present invention also includes other O-carboxylic acid-APP-ribose compounds and their corresponding synthetic methods (eg, O-propionyl-ADP-ribose and O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds .