论文部分内容阅读
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)儿童行为异常的发病机制。方法:对70例4～11岁打鼾儿童进行整夜多导睡眠仪监测,诊断为OSAHS40例,单纯鼾症30例,并以40例健康儿童为对照组。应用Conners简明症状问卷评定儿童行为问题。采用速率散射比浊法检测以上各组儿童血清C反应蛋白的含量。结果:OSAHS及单纯鼾症组存在行为问题的比率明显高于健康对照组,而两组之间差异无统计学意义。OSAHS组C反应蛋白含量(4.24mg/L)明显高于单纯鼾症组(2.76mg/L)及健康对照组(1.27mg/L);单纯鼾症组C反应蛋白含量高于健康对照组。OSAHS组伴有行为异常者血清C反应蛋白含量(4.63mg/L)明显高于不伴有行为异常者(3.23mg/L);单纯鼾症组伴有行为异常者血清C反应蛋白含量(3.63mg/L)明显高于不伴有行为异常者(1.76mg/L)。结论:OSAHS及单纯鼾症儿童有较多的行为问题出现。C反应蛋白的升高与OSAHS及单纯鼾症儿童的行为异常具有相关性。
Objective: To investigate the pathogenesis of behavioral abnormalities in children with obstructive sleep apnea-hypopnea syndrome (OSAHS). Methods: A total of 70 snoring children aged 4 to 11 years were monitored by overnight polysomnography. 40 cases were diagnosed as OSAHS, 30 cases were simple snoring, and 40 healthy children were used as control group. The Conners Concise Symptom Questionnaire was used to assess children’s behavioral problems. The contents of serum C-reactive protein in the above groups were detected by the rate nephelometry. Results: The rates of behavioral problems in OSAHS and simple snoring groups were significantly higher than those in healthy controls, but there was no significant difference between the two groups. The content of C-reactive protein (4.24mg / L) in OSAHS group was significantly higher than that in simple snore group (2.76mg / L) and healthy control group (1.27mg / L). The content of C-reactive protein in OSAHS group was higher than that in healthy control group. Serum C-reactive protein level (4.63mg / L) was significantly higher in patients with OSAHS than in those without behavioral abnormalities (3.23mg / L); Serum C-reactive protein mg / L) was significantly higher than those without behavioral abnormalities (1.76mg / L). Conclusion: There are more behavioral problems in children with OSAHS and simple snoring. C-reactive protein and OSAHS and simple snoring children with abnormal behavior is relevant.