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目的观察2型糖尿病合并糖尿病肾脏疾病的危险因素。方法回顾性总结我院2015年7月至2016年7月收治的623例2型糖尿病患者的临床资料,其中观察组为2型糖尿病合并糖尿病肾脏疾病患者,对照组为单纯2型糖尿病患者,分析2型糖尿病患者合并糖尿病肾脏疾病的危险因素。结果 623例患者,196例合并糖尿病肾脏疾病,发生率为31.46%;观察组病程、视网膜病变率、血肌酐、血尿酸、低密度脂蛋白胆固醇及24 h尿白蛋白水平明显高于对照组,差异有显著性意义(P<0.05);经多因素Logistic回归方程发现,体质量指数、病程、收缩压、血尿酸及吸烟等因素与2型糖尿病合并糖尿病肾脏疾病独立相关。结论 2型糖尿病合并糖尿病肾脏疾病与多种临床危险因素相关,降低血压及血尿酸水平,纠正低蛋白血症有利于控制糖尿病肾脏疾病的发生与恶化。
Objective To observe the risk factors of type 2 diabetes mellitus with diabetic nephropathy. Methods The clinical data of 623 type 2 diabetic patients admitted from July 2015 to July 2016 in our hospital were retrospectively reviewed. The observation group was type 2 diabetes mellitus with diabetic nephropathy and the control group was simple type 2 diabetes mellitus. Risk factors for diabetic nephropathy in type 2 diabetic patients. Results The disease course, the rate of retinopathy, serum creatinine, blood uric acid, low density lipoprotein cholesterol, 24 h urinary albumin in the 623 patients and 196 patients with diabetic nephropathy were significantly higher than those in the control group, The difference was significant (P <0.05). The multivariate Logistic regression equation found that body mass index, duration of disease, systolic blood pressure, serum uric acid and smoking were independently associated with type 2 diabetes mellitus and diabetic nephropathy. Conclusions Type 2 diabetes mellitus with diabetic nephropathy is associated with a variety of clinical risk factors, lowering blood pressure and serum uric acid levels and correcting hypoproteinemia are beneficial for controlling the occurrence and worsening of diabetic kidney disease.