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为了探讨γ干扰素（ＩＦＮ－γ）在免疫治疗和免疫化疗中的作用，作者以Ｋ５６２和ＭＫＮ４５人胃癌细胞为靶细胞，观察ＩＦＮ－γ对ＴＩＬ、ＬＡＫ细胞毒活性的影响；同时选用五种化疗药物，以ＳＧＣ７９０１人胃癌细胞为靶细胞，评价ＩＦＮ－γ对化疗药抗癌作用的影响。实验结果表明：（１）ＩＦＮ－γ明显增强ＴＩＬ和ＬＡＫ对两种肿瘤细胞的杀伤活性；（２）ＩＦＮ－γ显著增强五种化疗药物对ＳＧＣ７９０１胃癌细胞的抗癌效应。结果提示，ＩＦＮ－γ作为免疫治疗和免疫化疗的重要免疫调节剂，有一定的应用前景。
To investigate the role of IFN-γ in immunotherapy and immunochemotherapy, the authors used K562 and MKN45 human gastric cancer cells as target cells to observe the effect of IFN-γ on the cytotoxicity of TIL and LAK; Chemotherapy drugs targeting SGC7901 human gastric cancer cells were used to evaluate the effect of IFN-γ on the anti-cancer effects of chemotherapeutic drugs. The experimental results showed that: (1) IFN-γ significantly enhanced the killing activity of TIL and LAK on two kinds of tumor cells; (2) IFN-γ significantly enhanced the anticancer effect of five chemotherapy drugs on SGC7901 gastric cancer cells. The results suggest that IFN-γ has important application prospects as an important immunomodulator for immunotherapy and immunochemotherapy.