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目的 :观察血管内皮细胞生长因子结合缓释技术 ,促机械性TMR管道内血管生成的作用。方法 :利用机械钻在家兔左室前壁进行心肌钻孔 ,形成透室壁性心肌管道 ,实验组心肌管道内放入含VEGF及肝素的可吸收性多孔缓释微管 ;对照组放入不含VEGF及肝素的可吸收性多孔缓释微管。动物于术后8周处死 ,利用组织切片染色法 ,对照观察实验组和对照组TMR管道内血管生成状况。结果 :实验组TMR管道内血管生成的密度 /数量为 9.2 4± 0 .46条 /10× 4倍 ;对照组为 1.98± 0 .87条 /10× 4倍 ,两者具有非常显著性差异 ,P <0 .0 0 1。结论 :VEGF通过可吸收性多孔微管的缓释作用 ,对管道内血管的再生与重建具有非常明显的促进作用。
OBJECTIVE: To observe the effect of vascular endothelial growth factor combined with sustained-release technology to promote angiogenesis in mechanical TMR channels. Methods: Mechanical drilling was used to drill the myocardium in the anterior wall of left ventricle in rabbits to form a transmural myocardial tunnel. In the experimental group, an absorbable porous sustained-release microtubule containing VEGF and heparin was placed in the experimental group. Absorbable porous extended release microtubules without VEGF and heparin. The animals were sacrificed 8 weeks after the operation. Tissue sections were used to observe the angiogenesis in the TMR duct in the experimental and control groups. Results: The density and number of angiogenesis in the experimental group were 9.24 ± 0.46 / 10 × 4 times and 1.98 ± 0.87 / 10 × 4 times in the control group, both of which had very significant difference. P <0 .0 0 1. CONCLUSION: The sustained release of VEGF through porous micropipets can promote the regeneration and reconstruction of blood vessels in the duct.