感染是重症监护室致病及致死的第一位因素,缺乏特异的临床表现;其病原学诊断有赖于微生物培养,但受微生物自身生长周期的限制而不能及时提供结果,且使用抗生素、标本留取方法不当或标本量不足都可能导致假阴性结果,从而延误诊断,常常导致抗生素的过度或错误使用,增加了多重耐药及二重感染的机会。因此,寻找与感染严重程度密切相关的敏感性高、特异性强的标志物具有重要 Infection is the first factor in the ICU’s pathogenicity and lethality, and lacks specific clinical manifestations. Its etiological diagnosis depends on the culture of microorganisms, but it can not provide timely results due to the limitation of the growth cycle of the microorganisms and the use of antibiotics and specimens Improper methods or inadequate sample sizes can lead to false-negative results, which can delay diagnosis and often lead to over or misuse of antibiotics, increasing the chance of multiple drug resistance and double infection. Therefore, it is important to find highly sensitive and specific markers that are closely related to the severity of the infection