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目的：观察天花粉蛋白（ＴＣＳ）注射液致豚鼠全身过敏反应的情况。方法：用ＴＣＳ作为抗原，对豚鼠进行致敏和攻击。结果：ＴＣＳ可引起豚鼠发生全身过敏反应。在一定范围内，剂量与阳性率无明显关系；低于一定剂量，反应减少或不出现；剂量过高亦使反应率降低。随着攻击（致敏）次数和时间增加，阳性反应也相应提高。结论：ＴＣＳ对豚鼠有强的致敏性，剂量过低或过高均对过敏反应发生率有一定的影响
Objective: To observe the allergic reaction of guinea pigs caused by trichosanthin (TCS) injection. METHODS: Guinea pigs were sensitized and challenged with TCS as an antigen. Results: TCS can cause systemic allergic reactions in guinea pigs. Within a certain range, there is no obvious relationship between the dose and the positive rate; below a certain dose, the response is reduced or does not occur; too high a dose also reduces the reaction rate. As the number and time of attacks (sensitized) increase, the positive response increases accordingly. Conclusion: TCS has a strong sensitization in guinea pigs, too low dose or too high dose have a certain impact on the incidence of allergic reactions