恶性黑素瘤(MM)发病率和死亡率的逐年增加在许多国家已成为一个重要的公众健康问题。提高早期诊断水平直接关系患者生存率的提高。传统观点认为最能预测临床演变和预后的标志是肿瘤浸润性(B reslow厚度),但并不能全面预示恶性黑素瘤的生物学行为。近年来,随着对黑素瘤发病机制 The annual increase in the incidence and mortality of malignant melanoma (MM) has become an important public health issue in many countries. Improving the level of early diagnosis directly affects the survival rate of patients. The traditional view is that the most predictive marker of clinical evolution and prognosis is tumor invasiveness (B reslow thickness), but it does not fully predict the biological behavior of malignant melanoma. In recent years, with the pathogenesis of melanoma