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慢性皮质醇水平升高可以增加体脂,已明确见于库欣综合征。腹型肥胖在多种激素、代谢和循环特点等方面和库欣综合征具有相似的改变,糖皮质激素受体功能异常又加重了过量皮质醇给机体带来的不利影响。 皮质醇受体基因(G RL)外显子2的Asn363Ser多肤性可能与超重和对外源皮质激素敏
Chronic cortisol levels can increase body fat has been specifically found in Cushing’s syndrome. Abdominal obesity has similar changes in Cushing’s syndrome in a variety of hormones, metabolic and circulatory characteristics, and dysfunction of glucocorticoid receptor aggravates the adverse effects of excess cortisol on the body. Asn363Ser Proliferation of Exon 2 of Cortisol Receptor Gene (GRL) May Be Associated with Overweight and Exogenous Corticosteroid Sensitivity