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狼疮性肾炎(LN)是指系统性红斑狼疮(SLE)合并双肾不同病理类型的免疫性损害,同时伴有明显肾脏损害临床表现的疾病。其发病与免疫复合物形成、免疫细胞和细胞因子等免疫异常有关。除SLE全身表现外,临床主要表现为血尿、蛋白尿、肾功能不全等。本病属于中医学的“阴阳毒”“温毒发斑”“水肿”“腰痛”范畴。中医学认为,LN形成的内因多与先天不足、素体虚弱、肝肾亏损、气阴两虚、络脉瘀阻有关;外因多与感受邪毒,以及过度劳累、七情内伤、房事不节等有关。本文根据中医学辨证论治、对症用药的理论,从用药原则、用药方案、用药提示等方面,对LN中成药的合理应用进行了阐述。
Lupus nephritis (LN) is a disease of systemic lupus erythematosus (SLE) associated with different pathological types of both kidneys immune damage, accompanied by obvious clinical manifestations of renal damage. Its incidence and immune complex formation, immune cells and cytokines and other immune abnormalities. In addition to systemic manifestations of SLE, the clinical manifestations of hematuria, proteinuria, renal insufficiency and so on. The disease belongs to the traditional Chinese medicine “yin and yang poisoning” “warm spot” “edema” “low back pain” category. Chinese medicine believes that the internal causes of LN formation and congenitally deficient, physical weakness, liver and kidney loss, qi and yin deficiency, collaterals stasis related; external factors and feel evil poison, and overwork, seven emotions internal injuries, abstinence related. Based on the theory of TCM syndrome differentiation and symptomatic treatment, this paper elaborates the rational application of proprietary Chinese medicine (TCM) from the aspects of medication principle, medication plan and medication reminder.