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答胰岛B细胞功能受损是2型糖尿病重要的病理生理改变之一,临床上评价胰岛B细胞功能的方法主要通过测定血清胰岛素或C肽水平,目前临床上还不能评价人体胰岛B细胞的数量。在有些情况下(如短时间的糖毒性和脂毒性),胰岛素分泌功能会被暂时抑制,控制这些因素后胰岛素分泌功能会有所恢复。在新诊断2型糖尿病患者中,不论用胰岛素治疗或口服降糖药治疗都可观察到这一现象。
Islet B cell dysfunction is one of the important pathophysiological changes in type 2 diabetes. The clinical evaluation of islet B cell function is mainly through the determination of serum insulin or C-peptide levels, the current clinical evaluation of human islet B cells can not be the number . In some cases (such as short-term sugar toxicity and lipotoxicity), insulin secretion will be temporarily inhibited, control of these factors after insulin secretion will be restored. This is observed in newly diagnosed type 2 diabetic patients, whether treated with insulin or oral hypoglycemic agents.