论文部分内容阅读
目的探讨炎琥宁注射液治疗小儿轮状病毒腹泻的临床疗效。方法选取2015年4月—2016年4月丰城市妇幼保健院收治的小儿轮状病毒腹泻患儿80例,随机将所有患儿分成参照组和研究组,各40例。参照组患儿给予常规治疗,研究组患儿在参照组基础上采用炎琥宁注射液治疗。比较两组患儿临床疗效、治疗前后血清C反应蛋白(CRP)、白介素6(IL-6)和肌酸激酶同工酶(CK-MB)水平、症状消失时间(体温恢复正常时间、呕吐消失时间、大便性状以及大便次数恢复正常时间)及不良反应发生情况。结果研究组患儿总有效率高于参照组,差异有统计学意义(P<0.05)。治疗前两组患儿CRP、IL-6和CK-MB水平比较,差异无统计学意义(P>0.05);治疗后研究组患儿CRP、IL-6和CK-MB水平低于参照组,差异有统计学意义(P<0.05)。研究组患儿体温恢复正常时间、呕吐消失时间、大便性状恢复正常时间短于参照组,大便次数少于参照组,差异有统计学意义(P<0.05)。两组患儿均未发生严重不良反应。结论小儿轮状病毒腹泻患儿应用炎琥宁注射液治疗效果明显,可有效缩短症状恢复正常时间。
Objective To investigate the clinical efficacy of Yanhuning injection in treating pediatric rotavirus diarrhea. Methods Eighty children with pediatric rotavirus diarrhea admitted from April 2015 to April 2016 in Fengcheng MCH hospital were enrolled. All children were randomly divided into a reference group and a study group, with 40 cases in each group. The reference group of children given conventional treatment, the study group children in the reference group based on the use of Yan Hu Ning injection treatment. The clinical efficacy of the two groups were compared. The levels of serum C-reactive protein (CRP), interleukin 6 (IL-6) and creatine kinase MB (CK-MB), symptom disappearance time (normal body temperature returned to normal, vomiting disappeared Time, stool traits and stool frequency returned to normal time) and adverse reactions. Results The total effective rate in study group was higher than that in reference group, the difference was statistically significant (P <0.05). There was no significant difference in CRP, IL-6 and CK-MB levels between the two groups before treatment (P> 0.05). The levels of CRP, IL-6 and CK-MB in the study group were lower than those in the control group The difference was statistically significant (P <0.05). The recovery time of normal body temperature, vomiting disappearance time, stool recovery time in study group were shorter than those in reference group, and stool frequency was less than that in reference group. The difference was statistically significant (P <0.05). No serious adverse reactions occurred in both groups. Conclusion Infantile rotavirus diarrhea in children with the application of Yan Huaning injection treatment effect is obvious, can effectively shorten the time to return to normal symptoms.